1 | Adam Scharf, PhD | Boston University
Studies Toward the Synthesis of Complex Meroterpenoid Natural Products
2 | Ali Roghanian, PhD | Massachusetts Institute of Technology (MIT)
Novel Humanized Mouse Models of Cancer
3 | Alix Chan | Harvard/Broad
Discovery of a covalent kinase inhibitor from a DNA-encoded small-molecule library x protein library selection
4 | Ameet Shetty, PhD | Harvard Medica School
Spt5 plays vital roles in the control of sense and antisense transcription elongation
5 | Ami Ashar-Patel, PhD | UMass Medical School
Transcriptome wide analysis of 3’ mRNA ends in preeclampsia
6 | Amrendra Ajay, PhD | Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115
CRISPR mediated genome edited cells to study kidney fibrosis
7 | Andrew Wang, PhD | NIBR
Identification and mechanistic characterization of a new v-ATPase inhibitor, Naph62
8 | Archana Boopathy, PhD | Massachusetts Institute of Technology
Sustained immune responses following delivery of a HIV subunit vaccine using silk microneedle skin patches
9 | Cancan Huang, PhD | Harvard University
Tuning of the molecular conductance by single-molecular break junction
10 | Caroline Kotlowski, PhD | MIT Chemical Engineering
A tailored proteo-graphene surface as biosensor for screening chemically similar small molecules inspired by the honeybee’s olfaction
11 | Chiara Pighi, PhD | Department of Pathology, Boston Children's Hospital, Harvard Medical School
FBXO11 is recurrently mutated in Burkitt Lymphoma and its inactivation accelerates lymphomagenesis in Eµ-myc mice.
12 | Chirag Lakhani, PhD | Department of Biomedical Informatics
Building an Exposome API
13 | Christina Tognoni, PhD | Boston University
White matter neurons: New perspectives for Alzheimer’s disease
14 | Claire Doyle, PhD | Boston Children's Hospital & Harvard Medical School
The role of the mucosa in modulation of evoked resposnses in the spinal cord injured rat bladder
15 | Colles Price, PhD | Dana Farber Cancer Institute/Broad Institute of M.I.T. and Harvard
Integrated RNAi and CRISPR screen reveals novel dependencies in ovarian cancer
16 | Cynthia Gubbels, PhD | Boston Children's Hospital
Genome guided management in the NICU
17 | Daniel Ehlinger, PhD | Boston Children's Hospital
Global and cell-type specific disruptions of psychiatric risk gene CACNA1C alter ascending serotonin system activity.
18 | Deborah Flusberg, PhD | Merck Research Laboratories
Identification of G-Quadruplex Binding MYC Inhibitors Using Automated Ligand Identification System (ALIS)
19 | Edward Richards, PhD | Koch Institute
Model-driven design of TAMR inhibitors for therapeutic use in tumor promoting macrophages
20 | Elizabeth Smith | Tufts University School of Medicine
The Whole Tooth and Nothing but the Tooth: Bioengineered GelMA Tooth Bud Constructs for Future Applications in Implant Dentistry
21 | Emmanuel Virot, PhD | EPFL / Harvard
Transition towards buckling in coke cans
22 | Greggory Rice, PhD | Novartis Institutes for Biomedical Research
sTREAT: a fluorescent protein based reporter system for monitoring RNA nuclease processing events in cells
23 | Haihua Xiao, PhD | MIT
Development of Novel Platinum Agents with Unique Mechanism of Action for Drug Delivery
24 | Hicham Mahboubi, PhD | Novartis
Building a reporter system to assess repeat-associated translation: Application to screen genetic modulators of microsatellite expansion disorders
25 | Hyelim Cho, PhD | Novartis
Discovery and elucidation of the anti-melanoma mechanism of liminoid natural products
26 | Ingrid Aries, PhD | Boston Children's Hospital
PRC2 Inactivation Induces Primary Chemotherapy Resistance in T-cell Acute Lymphoblastic Leukemia by Upregulating the TRAP1 Mitochondrial Chaperone
27 | Irina Armean, PhD | MGH/Broad
Naturally occurring human variation suggests LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease
28 | Jaclyn Dunphy | Tufts University
Optogenetic control of exocytosis: Gaining a better understanding of the mechanisms underlying schizophrenia
29 | John Santa Maria, PhD | Merck Research Laboratories
Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase
30 | Junrui Cheng, PhD | Tufts University
Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization
31 | Keith Bentley, PhD | Massachusetts Institute of Technology
A Novel Methodology for More Efficient Synthesis of Pharmaceutically Relevant Compounds
32 | Kelly (Wen Li) Chen, PhD | MIT
Development of In-Vitro Microphysiological Systems to Interrogate Inter-Tissue Crosstalk for Applications in Disease Modeling and Drug Development
33 | Klaus Bonazza, PhD | Harvard Medical School / Boston Children's Hospital
Mechano-selective activation of a drug glycoprotein
34 | Kristie Hilliard, PhD | Merck
IL-17 Promotes Intestinal Epithelial Homeostasis: Functional Use of Human Intestinal 3D Organoids and Implications for Potential IBD Therapies
35 | Leah Bury, PhD | Whitehead Institute for Biomedical Research
Defining the Molecular Basis for Centromere Transcription
36 | Lei Ji, PhD | Novartis Institutes for Biomedical Research
The SIAH E3 ubiquitin ligases promote Wnt/beta-catenin signaling through mediating Wnt-induced Axin degradation
37 | Leigh Matano | Harvard Medical School
Accelerating the discovery of antibacterial compounds using pathway-directed whole cell screening
38 | Mahsa Zarei, PhD | Brigham and Women's Hospital,Harvard Medical school
IDH1 is post-transcriptionally regulated to promote a pro-survival phenotype in pancreatic cancer cells
39 | Margherita Perillo, PhD | Boston College
Positioning of subsets of nuclei at the neuromuscular and myotendinous junctions in muscles
40 | Maria Montiel, PhD | Marine Biological Laboratory
Correction of the Most Frequent Premature Termination Codon Mutations in CFTR by Site-directed RNA Editing
41 | Md Nurunnabi, PhD | Harvard Medical School-Massachusetts General Hospital
Oral Delivery of Therapeutic Gene Encoding Glucagon-Like Peptide 1 to Treat High Fat Diet-induced Diabetes
42 | Mehrdad Khajavi, PhD | Boston Children's Hospital
Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice
43 | Meltem Isik, PhD | Joslin Diabetes Center, Harvard Medical Shool
Regulation of Alternative Splicing by mTORC1 signaling in vivo
44 | Michael Cuccarese, PhD | Massachusetts General Hospital
Seeing Deeper with molecular probes
45 | Mikael Garabedian | Brandeis University
The F-BAR protein Hof1 and NPF Bud6 comprise a feedback loop for formin control and cellular actin cable assembly
46 | Muhammad Qadri, PhD | Tufts University
Pigeons fail to anticipate the remaining within-session sequence when trained with multiple sequences
47 | Mun Kyung Hwang, PhD | MIT/Koch Institute
The checkpoint kinase-regulated phosphoproteome drives a cytoskeleton-associated adaptive response to chemotherapy
48 | Muthunarayanan Muthiah, PhD | Mass general hospital and Harvard medical school
Therapeutic Effect of Gene loaded Nanoparticle Eluting Coronary Stent on Suppression of Post-Angioplasty Restenosis
49 | Neelakshi Hudda, PhD | Tufts University
Residential Ambient and In-Home Air Quality Impacts of Aviation-Related Emissions
50 | Octavian Bucur, PhD | Beth Israel Deaconess Medical Center, Harvard Medical School
Expansion Pathology: Physical Tissue Expansion for Nanoscale Imaging and Investigation of Clinical Specimens
51 | Parisa Shooshtari, PhD | Broad Institute
Integrative genetic and epigenetic analysis uncovers regulatory mechanisms of autoimmune disease
52 | Pooja Sharma, PhD | Harvard Medical School
Fragment based discovery of protein-protein interaction site ligands of a cytokine signalling pathway: Towards Non-ATP competitive JAK2 inhibitors
53 | Sanjoy Khan, PhD | Harvard School of Dental Medicine
Expression of McCune-Albright Syndrome causing GαsR201H mutation in mesenchymal progenitor cells causes Fibrous Dysplasia in mice
54 | Lindy Kahanovitz-Amir | Mass General Hospital
- Development of Analog-specific Immunoassays for Pharmacokinetic Studies of Insulin Lispro and Insulin Aspart*
55 | Sarani Ghoshal, PhD | MGH
Combination Therapy with a Liver Selective Acetyl-CoA Carboxylase Inhibitor ND-654 and Sorafenib Improves Efficacy in the Treatment of Cirrhotic Rats with Hepatocellular Carcinoma56 | Satoru Horiya, PhD | Brandeis University
Directed evolution of glycopeptides that bind to broadly neutralizing HIV antibodies for HIV vaccine design57 | Seungkyu Lee, PhD | Boston Children's Hospital
Identification of Potassium Channel Subtypes Involved in Human ALS Hyperexcitability by Patch-seq and Patch-RT-qPCR58 | Srinivasan Sakthivel, PhD | University of Copenhagen
Is an unknown functional gene causing heart malformations by birth?59 | Sumanta Day, PhD | Massachusetts Institute of Technology
A genome engineering approach for drug target identification in malaria parasites60 | Surya Singh, PhD | MIT
Label free methods to monitor ultra-violet radiation induced changes in skin cells61 | Tamara Zaytouni, PhD | Boston Children's Hospital
Critical role for the urea cycle in obesity-associated pancreatic cancer62 | Terence Wong | Broad Institute
Comprehensive cistromic characterization of SOX10, a lineage-specific genetic dependency in melanoma, via the integration of functional genomic approaches63 | Terence Wong | Broad Institute
Annual NextGen survey highlights the evolving needs of the postdoc and graduate student community at the Broad Institute64 | Tianmin Fu, PhD | Boston Childrens' Hospital
The triggering of death receptor signaling through helical assembly65 | Timothy Calamaras, PhD | Tufts Medical Center
Mixed lineage kinase 3 (MLK3), a novel PKGIα substrate, prevents maladaptive cardiac structural and functional changes in heart failure.66 | Tingyu Liu, PhD | Novartis Institute of Biomedical Research
An in vitro model to screen immunomodulation reagents for Juvenile Recurrent Respiratory Papillomatosis (JRRP)67 | Wei Chou Tseng, PhD | Pfizer
A schizophrenia-associated SNP in zinc transporter SLC39A8 causes deficits in glutamate receptor activity and elevates the innate immune response68 | Wei Liu, PhD | Pfizer
Mechanistic Insights into the KHK Dependent and Independent Fructose Metabolism69 | Weier Qi, PhD | Joslin Diabetes Center
Activation of Pyruvate Kinase M2 Prevents the Development of Diabetic Nephropathy: Identification of a Novel Target From the Joslin 50-Year Medalist Study70 | Xavier Michelet, PhD | Brigham and Women's Hospital
Obesity Induces Metabolic Reprogramming In Natural Killer Cells Preventing Cytotoxicity Against Tumors71 | Xiaojiang Li, PhD | MIT Senseable City Lab
Mapping urban streetscape environment using Google Street View72 | Xuanshi Liu, PhD | Boston Children's Hospital
Untargeted monitoring external and internal exposures in autism spectrum disorder73 | Xuebing Wu, PhD | Whitehead Institute/MIT/HHMI
Widespread Influence of 3’-end Structures on Mammalian mRNA Processing and Stability74 | Yi Wen Kong, PhD | MIT
Exploiting Rewiring kinase signaling with nanotechnology to augment the efficacy of frontline chemotherapy.75 | Yoojin Shin, PhD | MIT
Development of 3D Alzheimer’s disease-brain blood barrier model76 | Yuchun Guo, PhD | MIT Computer Science and Artificial Intelligence Laboratory
A novel k-mer set memory (KSM) motif representation improves regulatory variant prediction77 | Zhongjie Fu, PhD | Boston Children's Hospital / Harvard Medical School
Fibroblast growth factor 21 restores retinal neuronal function in type 1 diabetic mice